Role of Antidiarrhoeal Drugs as Adjunctive Therapies for Acute Diarrhoea in Children

Role of Antidiarrhoeal Drugs as Adjunctive Therapies for Acute Diarrhoea in Children

Acute diarrhoea is a leading cause of child mortality in developing countries. Principal pathogens include Escherichia coli, rotaviruses, and noroviruses. 90% of diarrhoeal deaths are attributable to inadequate sanitation. Acute diarrhoea is the second leading cause of overall childhood mortality and accounts for 18% of deaths among children under five. In 2004 an estimated 1.5 million children...

Antidiarrhoeal drugs for acute diarrhoea in children.

Phosphodiesterase inhibitors as adjunctive therapies for tuberculosis

Mycobacterium tuberculosis (Mtb) is one of the most successful The failure to control the global TB epidemic despite the availability human pathogens, and a key mechanism in its virulence arsenal is its ability to influence host immune responses to its advantage. In recent years it has become clear that one such mechanism pivots on bacterial-derived, secreted small molecules that are released f...

Adjunctive Therapies for Bacterial Keratitis

Bacterial keratitis is the most common type among all types of infectious keratitis. Currently, antibiotics are the main-stay of treatment. The objective of this systematic review is to review published clinical studies which discuss the adjunctive treatment of bacterial keratitis to guide clinical decision-making. We reviewed the role of a variety of medications and surgeries which can help in...

Thrombolysis and adjunctive therapies in acute myocardial infarction.

Thrombolysis and percutaneous transluminal angioplasty represent the cornerstone of the pharmacologic treatment of and the interventional approach to patients with myocardial infarction (MI). They are very effective. However, they are hampered by some critical limitations. Therefore, alternatives to standard thrombolytic therapy have been developed. Platelet glycoprotein (GP) IIb/IIIa blockade ...